Cutting Edge: The Transcription Factor Bob1 Counteracts B Cell Activation and Regulates miR-146a in B Cells

Cutting edge: The transcription factor Bob1 counteracts B cell activation and regulates miR-146a in B cells.

Mice lacking the lymphocyte-specific transcription factor Bob1 (also called OBF-1 or OCA-B) fail to generate germinal centers and a robust Ig response. We show that peripheral B cells in Bob1(-/-) mice bear characteristics of chronically activated or anergic-like B cells and identify the immunosuppressive microRNA-146a, together with other microRNAs, as novel transcriptional targets of Bob1. Th...

Cutting Edge: A/WySnJ Transitional B Cells

Cutting Edge: Direct Suppression of B Cells

The B cell-specific transcription factor BSAP regulates B cell proliferation

The B cell-specific activator protein (BSAP) is a DNA-binding transcription factor expressed in pro-B, pre-B, and mature B cells, but not in plasma cells. In this study, we explored the role of BSAP in B cell function by assessing how the content of this protein varies in cells driven by proliferative stimuli and, conversely, how artificial manipulation of BSAP activity affects cell proliferati...

Cutting edge: B cell antigen receptor signaling occurs outside lipid rafts in immature B cells.

B cell Ag receptor (BCR) signaling changes dramatically during B cell development, resulting in activation in mature B cells and apoptosis, receptor editing, or anergy in immature B cells. BCR signaling in mature B cells was shown to be initiated by the translocation of the BCR into cholesterol- and sphingolipid-enriched membrane microdomains that include the Src family kinase Lyn and exclude t...